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Recent Advances in Direct Catalytic Asymmetric Transformations under Proton‐Transfer Conditions
Author(s) -
Kumagai Naoya,
Shibasaki Masakatsu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100918
Subject(s) - catalysis , stereoselectivity , cooperativity , chemistry , proton , combinatorial chemistry , enantioselective synthesis , reaction conditions , computational chemistry , organic chemistry , physics , biochemistry , quantum mechanics
Cooperative catalysis has proven to be a particularly powerful strategy for promoting stereoselective organic transformations under mild reaction conditions. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and excellent control of the stereochemical course. By harnessing the power of cooperativity, various sets of stereoselective reactions proceed under mild proton‐transfer conditions with perfect atom economy. This Minireview summarizes our recent contributions to several CN and CC bond‐forming reactions in this field and related transformations.