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Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells
Author(s) -
Zhou Kejin,
Wang Yiguang,
Huang Xiaonan,
LubyPhelps Katherine,
Sumer Baran D.,
Gao Jinming
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100884
Subject(s) - endocytic cycle , micelle , förster resonance energy transfer , fluorescence , nanotechnology , nanoparticle , organelle , chemistry , biophysics , materials science , endocytosis , biochemistry , organic chemistry , biology , optics , physics , aqueous solution , cell
Switch it up : Tunable, pH‐responsive nanoparticles can be selectively activated in different endocytic compartments. At high pH values, micelle formation (see picture, left) quenches fluorescence by Förster resonance energy transfer. The micelles disassemble at low pH values, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug‐delivery applications.