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Nickel‐Catalyzed Cross‐Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents
Author(s) -
Xie LanGui,
Wang ZhongXia
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100683
Subject(s) - scope (computer science) , aryl , reagent , catalysis , combinatorial chemistry , chemistry , nickel , substrate (aquarium) , functional group , coupling reaction , iodide , computer science , medicinal chemistry , organic chemistry , biology , programming language , ecology , alkyl , polymer
Broad scope and good tolerance : An efficient cross‐coupling of aryltrimethylammonium iodide salts with aryl‐, methyl‐, and benzylzinc chlorides catalyzed by [Ni(PCy 3 ) 2 Cl 2 ] has been achieved (see scheme). The reaction involves cleavage of the CN bond and displays broad substrate scope and good functional group tolerance. NMP= N ‐methylpyrrolidine.
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