A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides | Zendy

Morimoto Hiroyuki | Zendy; Tsubogo Tetsu | Zendy; Litvinas Nichole D. | Zendy; Hartwig John F. | Zendy

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A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

Author(s) -

Morimoto Hiroyuki,

Tsubogo Tetsu,

Litvinas Nichole D.,

Hartwig John F.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100633

Subject(s) - trifluoromethyl , reagent , aryl , scope (computer science) , combinatorial chemistry , chemistry , phenanthroline , copper , organic chemistry , computer science , programming language , alkyl

Well compatible : The trifluoromethylations and perfluoroalkylations of aryl iodides and some aryl bromides with trifluoromethyl and perfluoroalkylcopper(I) phenanthroline complexes occur with broad scope at 25–50 °C (see scheme). The trifluoromethyl complex is prepared from inexpensive reagents and can be used in situ or isolated. The reactions tolerate a range of substituents and also occur with heteroaromatic systems.

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