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A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides
Author(s) -
Morimoto Hiroyuki,
Tsubogo Tetsu,
Litvinas Nichole D.,
Hartwig John F.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100633
Subject(s) - trifluoromethyl , reagent , aryl , scope (computer science) , combinatorial chemistry , chemistry , phenanthroline , copper , organic chemistry , computer science , programming language , alkyl
Well compatible : The trifluoromethylations and perfluoroalkylations of aryl iodides and some aryl bromides with trifluoromethyl and perfluoroalkylcopper(I) phenanthroline complexes occur with broad scope at 25–50 °C (see scheme). The trifluoromethyl complex is prepared from inexpensive reagents and can be used in situ or isolated. The reactions tolerate a range of substituents and also occur with heteroaromatic systems.