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Total Synthesis of (±)‐Decursivine and (±)‐Serotobenine: A Witkop Photocyclization/Elimination/O‐Michael Addition Cascade Approach
Author(s) -
Qin Hua,
Xu Zhengren,
Cui Yuxin,
Jia Yanxing
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100495
Subject(s) - michael reaction , cascade , total synthesis , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , chromatography
A photo op : The concise total syntheses of (±)‐decursivine and (±)‐serotobenine were achieved by using the titled cascade reaction, which is modeled on the biomimetic pathway. The synthesis of (±)‐decursivine, which exhibits antimalarial activity, was carried out in five steps without using protecting groups.

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