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Fluorogenic DNAzyme Probes as Bacterial Indicators
Author(s) -
Ali M. Monsur,
Aguirre Sergio D.,
Lazim Hadeer,
Li Yingfu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100477
Subject(s) - deoxyribozyme , fluorophore , cleave , dna , nucleic acid , rna , nucleotide , fluorescence , computational biology , bacteria , chemistry , biochemistry , biology , genetics , gene , physics , quantum mechanics
Lighting up bacteria : An RNA‐cleaving fluorescent DNAzyme (RFD) can produce a fluorescent signal in the crude extracellular mixture generated by live bacterial cells (see picture). These DNAzymes cleave a lone RNA linkage (R) embedded in a DNA chain and flanked by nucleotides labeled with a fluorophore (F) and a quencher (Q).
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