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A Colorimetric High‐Throughput Screening Method for Palladium‐Catalyzed Coupling Reactions of Aryl Iodides Using a Gold Nanoparticle‐Based Iodide‐Selective Probe
Author(s) -
Jung Eunhye,
Kim Sudeok,
Kim Yong,
Seo Seong Hyeok,
Lee Soo Suk,
Han Min Su,
Lee Sunwoo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100378
Subject(s) - aryl , palladium , iodide , catalysis , combinatorial chemistry , silver iodide , nanoparticle , chemistry , throughput , coupling (piping) , coupling reaction , computer science , organic chemistry , nanotechnology , materials science , telecommunications , layer (electronics) , silver halide , alkyl , metallurgy , wireless
Catching the couplings : A general and simple screening method for palladium‐catalyzed coupling reactions of aryl iodides utilizes gold nanoparticles. This assay was successfully employed in several aminations, α‐arylation of ketones, and decarboxylative couplings. 96 samples were screened in a few minutes.