Taking Advantage of the Ambivalent Reactivity of Ynamides in Gold Catalysis: A Rare Case of Alkyne Dimerization | Zendy

Kramer Søren | Zendy; Odabachian Yann | Zendy; Overgaard Jacob | Zendy; Rottländer Mario | Zendy; Gagosz Fabien | Zendy; Skrydstrup Troels | Zendy

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Taking Advantage of the Ambivalent Reactivity of Ynamides in Gold Catalysis: A Rare Case of Alkyne Dimerization

Author(s) -

Kramer Søren,

Odabachian Yann,

Overgaard Jacob,

Rottländer Mario,

Gagosz Fabien,

Skrydstrup Troels

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100327

Subject(s) - alkyne , reactivity (psychology) , chemistry , catalysis , ambivalence , product (mathematics) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , mathematics , medicine , alternative medicine , pathology , psychology , social psychology , geometry

A gold mine of results : A series of ynamides have been dimerized in the presence of a gold(I) complex. This unprecedented transformation involves the formation of a key keteniminium intermediate that reacts to form a variety of cyclic and acyclic products. The substitution pattern of the ynamide determines which product is formed (see scheme; EWG=electron‐withdrawing group, Ts= p ‐toluenesulfonyl).

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