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Enantioselective Total Synthesis of (−)‐Jiadifenolide
Author(s) -
Xu Jing,
Trzoss Lynnie,
Chang Weng K.,
Theodorakis Emmanuel A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100313
Subject(s) - enantioselective synthesis , annulation , total synthesis , ring (chemistry) , computer science , stereochemistry , chemistry , combinatorial chemistry , information retrieval , world wide web , organic chemistry , catalysis
Neurofunk : Highlights of the synthesis of 1 , a potent modulator of neurotrophic factors, include construction of the B ring through an asymmetric Robinson annulation, assembly of the E ring lactone through a novel acid‐induced cascade reaction, and Pd 0 ‐mediated carbomethoxylation and methylation reactions for the construction of the C and A rings, respectively.