Combining Gold(I)/Gold(III) Catalysis and CH Functionalization: A Formal Intramolecular [3+2] Annulation towards Tricyclic Indolines and Mechanistic Studies | Zendy

Zhang Guozhu | Zendy; Luo Yingdong | Zendy; Wang Yanzhao | Zendy; Zhang Liming | Zendy

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Combining Gold(I)/Gold(III) Catalysis and CH Functionalization: A Formal Intramolecular [3+2] Annulation towards Tricyclic Indolines and Mechanistic Studies

Author(s) -

Zhang Guozhu,

Luo Yingdong,

Wang Yanzhao,

Zhang Liming

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100293

Subject(s) - intramolecular force , selectfluor , moiety , annulation , octane , chemistry , combinatorial chemistry , tetrafluoroborate , catalysis , surface modification , aniline , medicinal chemistry , organic chemistry , ionic liquid

Gold rush : A combination of oxidative gold(I)/gold(III) catalysis and CH functionalization led to the first oxidative coupling between in situ generated alkyl gold reagents and C sp 2H bonds, affording tricyclic indolines through a formal [3+2] annulation between a vinyl group and an aniline moiety [see scheme; Tf=trifluoromethanesulfonyl, Selectfluor=1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)].

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