Simultaneous Concentration and Separation of Proteins in a Nanochannel | Zendy

Inglis David W. | Zendy; Goldys Ewa M. | Zendy; Calander Nils P. | Zendy

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Simultaneous Concentration and Separation of Proteins in a Nanochannel

Author(s) -

Inglis David W.,

Goldys Ewa M.,

Calander Nils P.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100236

Subject(s) - chemistry , concentration gradient , chromatography , electrophoresis , separation (statistics) , salt (chemistry) , conductivity , matrix (chemical analysis) , chemical physics , analytical chemistry (journal) , computer science , organic chemistry , machine learning

Balancing the forces : Conductivity gradient focusing in a nanochannel achieves simultaneous separation and concentration of proteins without a temperature gradient, membrane, matrix, ampholytes, or external pump. The electrophoretic force (see picture; red arrow) that dominates at the low‐salt side (−) balances the electro‐osmotic force (blue) at the high‐salt side (+).

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