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Regioselective Synthesis of Indenols by Rhodium‐Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes
Author(s) -
Muralirajan Krishnamoorthy,
Parthasarathy Kanniyappan,
Cheng ChienHong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100229
Subject(s) - alkyne , moiety , regioselectivity , aryl , catalysis , rhodium , chemistry , protonation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , ion , alkyl
Ketones and alkynes join together : The catalytic title reaction proceeds rapidly at 120 °C and requires only 1 hour for completion (see scheme). The reaction mechanism likely involves chelation‐assisted ortho CH activation, insertion of the alkyne moiety, carbocyclization, and protonation. Cp*=pentamethylcyclopentadienyl.