Regioselective Synthesis of Indenols by Rhodium‐Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes | Zendy

Muralirajan Krishnamoorthy | Zendy; Parthasarathy Kanniyappan | Zendy; Cheng ChienHong | Zendy

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Regioselective Synthesis of Indenols by Rhodium‐Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes

Author(s) -

Muralirajan Krishnamoorthy,

Parthasarathy Kanniyappan,

Cheng ChienHong

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100229

Subject(s) - alkyne , moiety , regioselectivity , aryl , catalysis , rhodium , chemistry , protonation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , ion , alkyl

Ketones and alkynes join together : The catalytic title reaction proceeds rapidly at 120 °C and requires only 1 hour for completion (see scheme). The reaction mechanism likely involves chelation‐assisted ortho CH activation, insertion of the alkyne moiety, carbocyclization, and protonation. Cp*=pentamethylcyclopentadienyl.

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