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Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols
Author(s) -
Wu QingFeng,
Liu WenBo,
Zhuo ChunXiang,
Rong ZiQiang,
Ye KeYin,
You ShuLi
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100206
Subject(s) - iridium , intramolecular force , allylic rearrangement , phosphoramidite , phenols , chemistry , ligand (biochemistry) , catalysis , diene , enantioselective synthesis , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , dna , biochemistry , natural rubber , oligonucleotide
Aromaticity lost : In the presence of [{Ir(cod)Cl} 2 ] and a binol‐derived phosphoramidite ligand, spirocyclohexadienone derivatives were obtained with up to 97 % ee through iridium‐catalyzed intramolecular asymmetric allylic dearomatization of phenols (see scheme; cod=cycloocta‐1,5‐diene).