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Electrostatic Control of Bioactivity
Author(s) -
Goldberger Joshua E.,
Berns Eric J.,
Bitton Ronit,
Newcomb Christina J.,
Stupp Samuel I.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100202
Subject(s) - nanofiber , amphiphile , peptide , chemistry , biophysics , laminin , epitope , neurite , bundle , amino acid , nanotechnology , biochemistry , materials science , biology , organic chemistry , immunology , in vitro , polymer , extracellular matrix , antibody , copolymer , composite material
The power of independence : When exhibited on the surface of self‐assembling peptide‐amphiphile nanofibers, the hydrophobic laminin‐derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).