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Single‐Molecule Determination of the Face‐Specific Adsorption of Amelogenin’s C‐Terminus on Hydroxyapatite
Author(s) -
Friddle Raymond W.,
Battle Keith,
Trubetskoy Vasily,
Tao Jinhui,
Salter E. Alan,
MoradianOldak Janet,
De Yoreo James J.,
Wierzbicki Andrzej
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100181
Subject(s) - amelogenin , face (sociological concept) , molecule , adsorption , key (lock) , nanotechnology , chemistry , crystallography , computational biology , computer science , information retrieval , materials science , gene , biochemistry , biology , sociology , computer security , organic chemistry , social science
On the face of it : An atomic force microscopy tip, functionalized with Amelogenin protein (Amel), is used to directly determine the single‐molecule, face‐specific free energy of Amel binding to crystalline hydroxyapatite (see picture). The experimental values compare well with those from molecular dynamics simulations and enable the key interactions controlling face‐specific binding to be identified.