Palladium‐Catalyzed Enantioselective Intramolecular Hydroarylation of Alkynes To Form Axially Chiral 4‐Aryl 2‐Quinolinones | Zendy

Shibuya Tetsuro | Zendy; Shibata Yu | Zendy; Noguchi Keiichi | Zendy; Tanaka Ken | Zendy

Premium

Palladium‐Catalyzed Enantioselective Intramolecular Hydroarylation of Alkynes To Form Axially Chiral 4‐Aryl 2‐Quinolinones

Author(s) -

Shibuya Tetsuro,

Shibata Yu,

Noguchi Keiichi,

Tanaka Ken

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201100152

Subject(s) - enantioselective synthesis , intramolecular force , palladium , cationic polymerization , aryl , chemistry , catalysis , ring (chemistry) , axial symmetry , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , mathematics , alkyl , geometry

A long‐awaited asymmetric version of the intramolecular hydroarylation of alkynes to form fused ring systems has been developed. A cationic palladium(II)/( S )‐xyl‐H 8 ‐binap complex was used to catalyze an enantioselective hydroarylation of alkynes at room temperature to furnish axially chiral 4‐aryl 2‐quinolinone derivatives in good yields with good enantioselectivity (see scheme; Bn=benzyl).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research