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Calcium Ions to Remotely Control the Reversible Switching of Secondary and Quaternary Structures in Bioconjugates
Author(s) -
Kühnle Romina I.,
Börner Hans G.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100141
Subject(s) - bioconjugation , peptide , chemistry , calcium , biophysics , conjugate , intramolecular force , ion , combinatorial chemistry , nanotechnology , biochemistry , materials science , stereochemistry , organic chemistry , biology , mathematical analysis , mathematics
A biomimetic strategy to modulate inter‐ and intramolecular Coulomb interactions of peptides allows for the reversible regulation of functions of peptide–polymer conjugates. Calcium ions are exploited as triggers to screen peptide charges, thereby switching the peptide secondary structure. This approach results in a reversible control mechanism for bioconjugate self‐assembly. Disassembly is feasible by regulating the Ca 2+ levels using competitive Ca 2+ binders.