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One‐Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients
Author(s) -
Vaxelaire Carine,
Winter Philipp,
Christmann Mathias
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100059
Subject(s) - combinatorial chemistry , active ingredient , sequence (biology) , chemistry , broad spectrum , nanotechnology , pharmacology , materials science , medicine , biochemistry
All in one : A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one‐pot reactions and is poised to speed up the synthesis of medicinally relevant drug compounds.