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Efficient Gold(I)‐Catalyzed Direct Intramolecular Hydroalkylation of Unactivated Alkenes with α‐Ketones
Author(s) -
Xiao YaPing,
Liu XinYuan,
Che ChiMing
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100044
Subject(s) - intramolecular force , catalysis , chemistry , combinatorial chemistry , stereochemistry , organic chemistry
Easy access by gold : The Au I ‐catalyzed title reaction provides simple and efficient access to highly substituted cyclic compounds with excellent yields and good diastereoselectivity. This transformation constitutes the first example of transition‐metal‐catalyzed direct hydroalkylation of unactivated alkenes with simple α‐ketone groups in the absence of additive reagents. Bn=benzyl, Ts=tosyl.