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Phosphorescent Nanoscale Coordination Polymers as Contrast Agents for Optical Imaging
Author(s) -
Liu Demin,
Huxford Rachel C.,
Lin Wenbin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201008277
Subject(s) - phosphorescence , nanoscopic scale , biocompatibility , polymer , nanotechnology , ethylene glycol , peg ratio , materials science , optical imaging , kinetics , chemistry , organic chemistry , business , fluorescence , physics , finance , quantum mechanics , optics , metallurgy , composite material
Seeing is believing : Phosphorescent nanoscale coordination polymers (NCPs) with unprecedentedly high dye loadings were coated with thin silica shells to tune the dye release kinetics (see picture). Further functionalization of the NCP/silica particles with poly(ethylene glycol) (PEG) and PEG‐anisamide enhanced their biocompatibility and targeting ability, allowing cancer‐specific imaging of human lung cancer H460 cells.