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A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte
Author(s) -
Xu Zhongli,
Ding Ling,
Hertweck Christian
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201008265
Subject(s) - polyketide , biosynthesis , valine , stereochemistry , chemistry , polyketide synthase , biochemistry , reductase , enzyme , amino acid
Sharing a branch : The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl‐CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis.