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Quantitative 3D Analysis of Nitric Oxide Diffusion in a 3D Artery Model Using Sensor Particles
Author(s) -
Matsusaki Michya,
Amemori Suzuka,
Kadowaki Koji,
Akashi Mitsuru
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201008204
Subject(s) - nitric oxide , cyclic guanosine monophosphate , biophysics , nitric oxide synthase , blood vessel , chemistry , vasodilation , microbiology and biotechnology , extracellular , biochemistry , biology , endocrinology , organic chemistry
NO blood lost : Three‐dimensional analysis of nitric oxide (NO) diffusion in a blood vessel in response to drug stimulation was achieved by using 3D artery models including NO sensor particles (see picture). The quantity and diffusion distance of NO in the five‐layered models were almost the same as those for the in vivo blood vessel response. This method enables an in vitro bioassay of tissue responses instead of animal experiments.