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Palladium‐Catalyzed Cascade Reaction for the Synthesis of Substituted Isoindolines
Author(s) -
Williams Florence J.,
Jarvo Elizabeth R.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201008160
Subject(s) - palladium , aryl , cascade , catalysis , combinatorial chemistry , chemistry , computer science , organic chemistry , alkyl , chromatography
Arylate then cyclize : A palladium(II)‐catalyzed cascade sequence has been developed to provide highly diastereomerically enriched cis ‐1‐aryl‐3‐vinyl isoindolines (see scheme). The method uses commercially available aryl boronic acids and boroxine compounds containing a variety of electron‐rich, ‐neutral, or ‐poor aromatic groups. Ts=4‐toluenesulfonyl.
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