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Reply to T. W. Bentley: Limitations of the s ( E + N ) and Related Equations
Author(s) -
Mayr Herbert
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007923
Subject(s) - simple (philosophy) , computer science , scale (ratio) , reactivity (psychology) , content (measure theory) , mathematics , philosophy , epistemology , physics , mathematical analysis , medicine , alternative medicine , pathology , quantum mechanics
Simple and unambiguous : In the equation log k = s ( E + N ), the nucleophilicity N is obtained through the intercepts on the abscissa of linear log k versus E (electrophilicity) correlations. This approach places nucleophiles that differ by more than 30 orders of magnitude in reactivity on a single scale that can be used as a guide for designing organic syntheses. The equation in question is not only more practical but is also more precise than Bentley's alternatives.