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Synthesis of 64 Cu II –Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual‐Modality PET–MRI Agent
Author(s) -
Torres Martin de Rosales Rafael,
Tavaré Richard,
Paul Rowena L.,
JaureguiOsoro Maite,
Protti Andrea,
Glaria Arnaud,
Varma Gopal,
Szanda Istvan,
Blower Philip J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007894
Subject(s) - superparamagnetism , nanoparticle , iron oxide , radiochemistry , materials science , in vivo , chemistry , mri contrast agent , nanomedicine , gadolinium , nuclear magnetic resonance , nuclear chemistry , nanotechnology , magnetization , physics , microbiology and biotechnology , quantum mechanics , magnetic field , metallurgy , biology
A novel bifunctional chelator combines a dithiocarbamate group for binding the positron‐emitter 64 Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare‐earth metal oxides. The dual PET–MR imaging capabilities of this approach are demonstrated in vivo by imaging lymph nodes using both imaging modalities.