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Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins
Author(s) -
Yoo Seong Il,
Yang Ming,
Brender Jeffrey R.,
Subramanian Vivekanandan,
Sun Kai,
Joo Nam Eok,
Jeong SooHwan,
Ramamoorthy Ayyalusamy,
Kotov Nicholas A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007824
Subject(s) - amyloid (mycology) , fibrillation , amyloid fibril , peptide , nanoparticle , biophysics , mechanism (biology) , chemistry , biochemistry , nanotechnology , materials science , amyloid β , medicine , biology , atrial fibrillation , epistemology , inorganic chemistry , philosophy , disease
Nanoparticles for amyloid diseases : CdTe nanoparticles (NPs) can efficiently prevent fibrillation of amyloid peptides; the process is based on the multiple binding of Aβ oligomers to CdTe NPs. The molar efficiency and the inhibition mechanism displayed by the NPs are analogous to the mechanism found for proteins responsible for the prevention of amyloid fibrillation in the human body.