Photoactivatable and Cell‐Membrane‐Permeable Phosphatidylinositol 3,4,5‐Trisphosphate | Zendy

Mentel Matthias | Zendy; Laketa Vibor | Zendy; Subramanian Devaraj | Zendy; Gillandt Hartmut | Zendy; Schultz Carsten | Zendy

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Photoactivatable and Cell‐Membrane‐Permeable Phosphatidylinositol 3,4,5‐Trisphosphate

Author(s) -

Mentel Matthias,

Laketa Vibor,

Subramanian Devaraj,

Gillandt Hartmut,

Schultz Carsten

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007796

Subject(s) - phosphatidylinositol , flash (photography) , derivative (finance) , sequence (biology) , chemistry , inositol , membrane , computational biology , microbiology and biotechnology , biochemistry , biology , signal transduction , receptor , physics , optics , financial economics , economics

Unleashed inside cells : The signaling molecule PI(3,4,5)P 3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight‐step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection (“uncaging”) with a laser flash, in live cells.

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