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Photoactivatable and Cell‐Membrane‐Permeable Phosphatidylinositol 3,4,5‐Trisphosphate
Author(s) -
Mentel Matthias,
Laketa Vibor,
Subramanian Devaraj,
Gillandt Hartmut,
Schultz Carsten
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007796
Subject(s) - phosphatidylinositol , flash (photography) , derivative (finance) , sequence (biology) , chemistry , inositol , membrane , computational biology , microbiology and biotechnology , biochemistry , biology , signal transduction , receptor , physics , optics , financial economics , economics
Unleashed inside cells : The signaling molecule PI(3,4,5)P 3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight‐step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection (“uncaging”) with a laser flash, in live cells.