Enantioselective Ficini Reaction: Ruthenium/PNNP‐Catalyzed [2+2] Cycloaddition of Ynamides with Cyclic Enones | Zendy

Schotes Christoph | Zendy; Mezzetti Antonio | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantioselective Ficini Reaction: Ruthenium/PNNP‐Catalyzed [2+2] Cycloaddition of Ynamides with Cyclic Enones

Author(s) -

Schotes Christoph,

Mezzetti Antonio

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007753

Subject(s) - ruthenium , cycloaddition , enantioselective synthesis , yield (engineering) , adduct , catalysis , chemistry , chloride , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy

Chiral cyclobuteneamides made easy : Double chloride abstraction from the ruthenium/PNNP complex 1 in the presence of unsaturated β‐keto esters 2 gives the dicationic adducts [Ru( 2 )(PNNP)] 2+ ( 3 ) that catalyze the [2+2] cycloaddition of a variety of ynamides 4 to produce cyclobuteneamides 5 with high yield and enantioselectivity (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research