Optimal Codon Choice Can Improve the Efficiency and Fidelity of  N ‐Methyl Amino Acid Incorporation into Peptides by In‐Vitro Translation | Zendy

Subtelny Alexander O. | Zendy; Hartman Matthew C. T. | Zendy; Szostak Jack W. | Zendy

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Optimal Codon Choice Can Improve the Efficiency and Fidelity of N ‐Methyl Amino Acid Incorporation into Peptides by In‐Vitro Translation

Author(s) -

Subtelny Alexander O.,

Hartman Matthew C. T.,

Szostak Jack W.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007686

Subject(s) - translation (biology) , amino acid , in vitro , peptide , codon usage bias , computational biology , chemistry , computer science , fidelity , combinatorial chemistry , biochemistry , biology , gene , messenger rna , genome , telecommunications

May the best codon win : N ‐methyl amino acids ( N ‐Me AAs) are important modifications found in several nonribosomal peptide therapeutics. Previously, it was shown that three N ‐Me AAs are efficiently incorporated into peptides using a cell‐free in‐vitro translation system. Now, the incorporation of these N ‐Me AAs has been optimized by varying the template codon.

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