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Perhaloalkylation of Metal Enolates—Unconventional and Versatile
Author(s) -
Amatov Tynchtyk,
Jahn Ullrich
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007672
Subject(s) - reactivity (psychology) , chemistry , metal , organic chemistry , natural (archaeology) , combinatorial chemistry , computational chemistry , history , archaeology , medicine , alternative medicine , pathology
Radically unconventional : Natural products with di‐ and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in which enolate reactivity and radical reactivity are merged (see scheme; Bn=benzyl).