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A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
Author(s) -
Jessen Henning Jacob,
Schumacher Andreas,
Shaw Travis,
Pfaltz Andreas,
Gademann Karl
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007671
Subject(s) - total synthesis , bifunctional , stereoselectivity , neurite , stereochemistry , chemistry , combinatorial chemistry , biochemistry , in vitro , catalysis
Unus pro omnibus : The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non‐invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC‐12 cell line.