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The Binding of Fluorophores to Proteins Depends on the Cellular Environment
Author(s) -
Kim Yun Kyung,
Lee JunSeok,
Bi Xuezhi,
Ha HyungHo,
Ng Shin Hui,
Ahn Younghoon,
Lee JaeJung,
Wagner Bridget K.,
Clemons Paul A.,
Chang YoungTae
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007626
Subject(s) - derivative (finance) , intracellular , chemistry , mitochondrion , thiol , covalent bond , computational biology , biochemistry , microbiology and biotechnology , computer science , biology , business , organic chemistry , finance
Lighten up! To investigate intracellular binders of myotube‐specific probes, a thiol‐reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.