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Efficient Hydrogenation of Ketones Catalyzed by an Iron Pincer Complex
Author(s) -
Langer Robert,
Leitus Gregory,
BenDavid Yehoshoa,
Milstein David
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007406
Subject(s) - pincer movement , catalysis , ketone , homogeneous , chemistry , homogeneous catalysis , noyori asymmetric hydrogenation , hydrogen , organic chemistry , catalytic hydrogenation , combinatorial chemistry , medicinal chemistry , mathematics , combinatorics , ruthenium
Reductions made easy : A highly efficient iron catalyst effects the homogeneous hydrogenation of ketones under very mild conditions (see scheme). A mechanism including the insertion of the ketone into the FeH bond, followed by addition of hydrogen to a dearomatized intermediate is proposed.