Total Synthesis of Aspergillide A and B Based on the Transannular Oxy‐Michael Reaction | Zendy

Kanematsu Makoto | Zendy; Yoshida Masahiro | Zendy; Shishido Kozo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of Aspergillide A and B Based on the Transannular Oxy‐Michael Reaction

Author(s) -

Kanematsu Makoto,

Yoshida Masahiro,

Shishido Kozo

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007327

Subject(s) - michael reaction , tetrahydropyran , metathesis , total synthesis , chemistry , salt metathesis reaction , stereochemistry , organic chemistry , ring (chemistry) , catalysis , polymer , polymerization

Keys to the kingdom : A highly efficient and diastereoselective transannular oxy‐Michael reaction for the construction of the syn ‐ and anti ‐tetrahydropyran units from a common 14‐membered macrolactone is the key step for the total synthesis of aspergillide A and B (see scheme; CM=cross‐metathesis, HWE=Horner–Wadsworth–Emmons, TBS= tert ‐butyldimethylsilyl).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research