Premium
Synthesis of (−)‐Viriditoxin: A 6,6′‐Binaphthopyran‐2‐one that Targets the Bacterial Cell Division Protein FtsZ
Author(s) -
Park Young Sam,
Grove Charles I.,
GonzálezLópez Marcos,
Urgaonkar Sameer,
Fettinger James C.,
Shaw Jared T.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007298
Subject(s) - ftsz , stereocenter , division (mathematics) , catalysis , combinatorial chemistry , chemistry , natural product , computer science , enantioselective synthesis , cell division , computational biology , stereochemistry , cell , biology , organic chemistry , biochemistry , arithmetic , mathematics
Remote control : Vanadium catalysts provide the key to synthesizing the bacteria‐fighting natural product viriditoxin. An achiral catalyst shows modest levels of remote diastereocontrol induced by the lactone stereogenic center and chiral catalysts can be used to enhance or reverse this inherent selectivity.