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Reversible Insertion of Aldehydes and Ketones into C sp 3 H Bonds of Chiral Bis(oxazoline)/Iridium Complexes
Author(s) -
Castillo M. Rosa,
Martín Marta,
Fraile José M.,
Mayoral José A.,
Sola Eduardo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007292
Subject(s) - iridium , oxazoline , chemistry , combinatorial chemistry , enantiomer , medicinal chemistry , photochemistry , stereochemistry , organic chemistry , catalysis
BOX of tricks : Facile, reversible, and diastereoselective functionalizations of methylene CH bonds with carbonyl compounds have been observed within chiral bis(oxazoline)/iridium complexes (see structure; O red, N blue, P orange, Ir purple). These reactions are described and discussed together with the classic CH oxidative additions to iridium that occur within these same compounds.