Mild and Selective H/D Exchange at the β Position of Aromatic α‐Olefins by N‐Heterocyclic Carbene–Hydride–Rhodium Catalysts | Zendy

Di Giuseppe Andrea | Zendy; Castarlenas Ricardo | Zendy; PérezTorrente Jesús J. | Zendy; Lahoz Fernando J. | Zendy; Polo Victor | Zendy; Oro Luis A. | Zendy

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Mild and Selective H/D Exchange at the β Position of Aromatic α‐Olefins by N‐Heterocyclic Carbene–Hydride–Rhodium Catalysts

Author(s) -

Di Giuseppe Andrea,

Castarlenas Ricardo,

PérezTorrente Jesús J.,

Lahoz Fernando J.,

Polo Victor,

Oro Luis A.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007238

Subject(s) - carbene , steric effects , rhodium , chemistry , catalysis , selectivity , hydride , medicinal chemistry , combinatorial chemistry , organic chemistry , hydrogen

Pacman bites selectively! Stable rhodium(III)–N‐heterocyclic carbene–hydride complexes (Pacman‐like catalysts) are highly active and selective catalysts for H/D exchange at the β position of aromatic α‐olefins (see picture). The interplay between bulky N‐heterocyclic carbene and quinolinate ligands determines the size of the steric window responsible for this selectivity.

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