Premium
Mild and Selective H/D Exchange at the β Position of Aromatic α‐Olefins by N‐Heterocyclic Carbene–Hydride–Rhodium Catalysts
Author(s) -
Di Giuseppe Andrea,
Castarlenas Ricardo,
PérezTorrente Jesús J.,
Lahoz Fernando J.,
Polo Victor,
Oro Luis A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007238
Subject(s) - carbene , steric effects , rhodium , chemistry , catalysis , selectivity , hydride , medicinal chemistry , combinatorial chemistry , organic chemistry , hydrogen
Pacman bites selectively! Stable rhodium(III)–N‐heterocyclic carbene–hydride complexes (Pacman‐like catalysts) are highly active and selective catalysts for H/D exchange at the β position of aromatic α‐olefins (see picture). The interplay between bulky N‐heterocyclic carbene and quinolinate ligands determines the size of the steric window responsible for this selectivity.