Membrane‐Bound Stable Glycosyltransferases: Highly Oriented Protein Immobilization by a C‐Terminal Cationic Amphipathic Peptide | Zendy

Naruchi Kentaro | Zendy; Nishimura ShinIchiro | Zendy

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Membrane‐Bound Stable Glycosyltransferases: Highly Oriented Protein Immobilization by a C‐Terminal Cationic Amphipathic Peptide

Author(s) -

Naruchi Kentaro,

Nishimura ShinIchiro

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007153

Subject(s) - glycosyltransferase , amphiphile , fucosyltransferase , cationic polymerization , peptide , membrane , chemistry , enzyme , biochemistry , recombinant dna , copolymer , gene , organic chemistry , polymer

Turning tail : The specific functions of C‐terminal cationic amphipathic peptide in the formation of bacterial membrane‐bound glycosyltransferases have been demonstrated. This mechanism was applied to a general concept that allows highly oriented immobilization of enzymes on membrane‐mimetic solid surfaces, such as recombinant full‐length H. pylori α1,3‐fucosyltransferase on a magnetic bead (see picture).

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