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Yb III ‐HPDO3A: A Dual pH‐ and Temperature‐Responsive CEST Agent
Author(s) -
Delli Castelli Daniela,
Terreno Enzo,
Aime Silvio
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007105
Subject(s) - chemistry , dual (grammatical number) , nuclear magnetic resonance , magnetic resonance imaging , in vivo , physics , philosophy , radiology , medicine , linguistics , microbiology and biotechnology , biology
A multiple response : Yb III ‐HPDO3A has been used for the development of a magnetic resonance imaging method that is able to assess pH value and temperature simultaneously, irrespective of the concentration of the complex (see graph). This contrast agent has potential in a clinical setting as it shows the same stability and in vivo pharmacokinetic properties as Gd III ‐HPDO3A, which is already used in clinical practices under the trade name of ProHance.