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Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease
Author(s) -
Geng Jie,
Li Meng,
Ren Jinsong,
Wang Enbo,
Qu Xiaogang
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007067
Subject(s) - amyloid (mycology) , peptide , chemistry , amyloid β , biochemistry , computational biology , disease , medicine , biology , inorganic chemistry
Inorganic amyloid inhibitors : Four types of polyoxometalates (POMs) were found to be efficient inhibitors of amyloid formation by amyloid β peptides (Aβ; see picture: unlike the top POM (red), the bottom POM (dark green) inhibited amyloid formation). The inhibition selectivity of POMs is due to size‐specific electrostatic interactions between POMs and Aβ through binding to the positively charged His13–Lys16 cluster region of Aβ.