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Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390
Author(s) -
Murphy Annabel C.,
Fukuda Daisuke,
Song Zhongshu,
Hothersall Joanne,
Cox Russell J.,
Willis Christine L.,
Thomas Christopher M.,
Simpson Thomas J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007029
Subject(s) - mupirocin , microbiology and biotechnology , biology , staphylococcus aureus , polyketide , gene cluster , mutant , pseudoalteromonas , plasmid , nonribosomal peptide , gene , methicillin resistant staphylococcus aureus , bacteria , biosynthesis , genetics , 16s ribosomal rna
New drugs from marine bugs : The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin‐resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild‐type and mutant strains and from mutagenesis experiments with mutant strains.