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Controlled Self‐Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents
Author(s) -
Liang Gaolin,
Ronald John,
Chen Yuanxin,
Ye Deju,
Pandit Prachi,
Ma Man Lung,
Rutt Brian,
Rao Jianghong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201007018
Subject(s) - library science , molecular imaging , nuclear medicine , medicine , computer science , microbiology and biotechnology , in vivo , biology
Gd smart : MRI contrast agents are presented that are based on a biocompatible condensation reaction. Upon reduction, a gadolinium‐containing cell‐permeable small‐molecule probe condenses into cyclic oligomers that subsequently self‐assemble into nanoparticles (NPs) with enhanced relaxivity (by 110 % at 1.5 T and 35 °C, and 104 % in live cells at 0.5 T).