Controlled Self‐Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents | Zendy

Liang Gaolin | Zendy; Ronald John | Zendy; Chen Yuanxin | Zendy; Ye Deju | Zendy; Pandit Prachi | Zendy; Ma Man Lung | Zendy; Rutt Brian | Zendy; Rao Jianghong | Zendy

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Controlled Self‐Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents

Author(s) -

Liang Gaolin,

Ronald John,

Chen Yuanxin,

Ye Deju,

Pandit Prachi,

Ma Man Lung,

Rutt Brian,

Rao Jianghong

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007018

Subject(s) - library science , molecular imaging , nuclear medicine , medicine , computer science , microbiology and biotechnology , in vivo , biology

Gd smart : MRI contrast agents are presented that are based on a biocompatible condensation reaction. Upon reduction, a gadolinium‐containing cell‐permeable small‐molecule probe condenses into cyclic oligomers that subsequently self‐assemble into nanoparticles (NPs) with enhanced relaxivity (by 110 % at 1.5 T and 35 °C, and 104 % in live cells at 0.5 T).

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