Access to High Levels of Molecular Complexity by One‐Pot Iridium/Enamine Asymmetric Catalysis | Zendy

Quintard Adrien | Zendy; Alexakis Alexandre | Zendy; Mazet Clément | Zendy

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Access to High Levels of Molecular Complexity by One‐Pot Iridium/Enamine Asymmetric Catalysis

Author(s) -

Quintard Adrien,

Alexakis Alexandre,

Mazet Clément

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201007001

Subject(s) - iridium , electrophile , nucleophile , allylic rearrangement , enantioselective synthesis , cationic polymerization , catalysis , isomerization , enamine , chemistry , combinatorial chemistry , organic chemistry

Independent workers with team spirit : A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organocatalysts has been developed for the highly enantioselective α functionalization of aldehydes (see scheme: up to 66 % yield, d.r. 49:1, 99 % ee ). The reaction displayed useful generality with respect to both the nucleophile and the electrophile.

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