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A Chiral N ‐Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor
Author(s) -
Johnston Jeffrey N.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006951
Subject(s) - enantioselective synthesis , phosphoric acid , catalysis , chemistry , intramolecular force , brønsted–lowry acid–base theory , combinatorial chemistry , medicinal chemistry , organic chemistry
Nitrogen enriched : The continuing quest for Brønsted acid catalysts that address unmet selectivity needs in organic synthesis has resulted in a new chiral phosphoric acid derivative. At the heart of this catalyst is a hydrogen‐bond donor (NH) that promotes an enantioselective intramolecular addition of oxygen (OH) to an azomethine (CN). Diversity within a privileged chiral architecture invariably leads to new catalytic enantioselective chemical reactions.