A Chiral  N ‐Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor | Zendy

Johnston Jeffrey N. | Zendy

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A Chiral N ‐Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor

Author(s) -

Johnston Jeffrey N.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201006951

Subject(s) - enantioselective synthesis , phosphoric acid , catalysis , chemistry , intramolecular force , brønsted–lowry acid–base theory , combinatorial chemistry , medicinal chemistry , organic chemistry

Nitrogen enriched : The continuing quest for Brønsted acid catalysts that address unmet selectivity needs in organic synthesis has resulted in a new chiral phosphoric acid derivative. At the heart of this catalyst is a hydrogen‐bond donor (NH) that promotes an enantioselective intramolecular addition of oxygen (OH) to an azomethine (CN). Diversity within a privileged chiral architecture invariably leads to new catalytic enantioselective chemical reactions.

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