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Specific Blocking of CREB/DNA Binding by Cyclometalated Platinum(II) Complexes
Author(s) -
Wang Ping,
Leung ChungHang,
Ma DikLung,
Sun Raymond WaiYin,
Yan SiuCheong,
Chen QingShou,
Che ChiMing
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006887
Subject(s) - dna , creb , groove (engineering) , platinum , transcription factor , computational biology , binding site , blocking (statistics) , minor groove , block (permutation group theory) , chemistry , computer science , gene , combinatorial chemistry , biology , biochemistry , mathematics , combinatorics , engineering , computer network , catalysis , mechanical engineering
In the groove : The unique major‐groove‐binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.