Access to Biomolecular Assemblies through One‐Pot Triple Orthogonal Chemoselective Ligations | Zendy

Galibert Mathieu | Zendy; Renaudet Olivier | Zendy; Dumy Pascal | Zendy; Boturyn Didier | Zendy

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Access to Biomolecular Assemblies through One‐Pot Triple Orthogonal Chemoselective Ligations

Author(s) -

Galibert Mathieu,

Renaudet Olivier,

Dumy Pascal,

Boturyn Didier

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201006867

Subject(s) - cycloaddition , oxime , thioether , azide , computer science , combinatorial chemistry , alkyne , chemistry , click chemistry , stereochemistry , organic chemistry , catalysis

Three into one will go : The consecutive combination of three orthogonal chemoselective reactions (oxime ligation, thioether addition, and copper(I)‐catalyzed alkyne–azide cycloaddition (CuAAC)) in a sequential one‐pot approach allows the syntheses of highly sophisticated biomolecular compounds without intervening isolations and protection schemes (see picture; ODN=oligodeoxynucleotide).

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