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Access to Biomolecular Assemblies through One‐Pot Triple Orthogonal Chemoselective Ligations
Author(s) -
Galibert Mathieu,
Renaudet Olivier,
Dumy Pascal,
Boturyn Didier
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006867
Subject(s) - cycloaddition , oxime , thioether , azide , computer science , combinatorial chemistry , alkyne , chemistry , click chemistry , stereochemistry , organic chemistry , catalysis
Three into one will go : The consecutive combination of three orthogonal chemoselective reactions (oxime ligation, thioether addition, and copper(I)‐catalyzed alkyne–azide cycloaddition (CuAAC)) in a sequential one‐pot approach allows the syntheses of highly sophisticated biomolecular compounds without intervening isolations and protection schemes (see picture; ODN=oligodeoxynucleotide).