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One‐Step Homogeneous DNA Assay with Single‐Nanoparticle Detection
Author(s) -
Han Guojun,
Xing Zhi,
Dong Yanhua,
Zhang Sichun,
Zhang Xinrong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006838
Subject(s) - homogeneous , nanoparticle , dna , colloidal gold , inductively coupled plasma mass spectrometry , chemistry , particle (ecology) , population , analytical chemistry (journal) , mass spectrometry , chromatography , nanotechnology , microbiology and biotechnology , materials science , biology , biochemistry , physics , medicine , ecology , thermodynamics , environmental health
Staying single : A DNA hybridization assay employs gold‐nanoparticle (AuNP) probes and single‐particle inductively coupled plasma spectrometry (ICP‐MS; see picture). The degree of aggregation of AuNPs is characterized by simultaneous measurement of decreased concentrations of the AuNP population and increased individual sizes.