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Label‐Free Detection of Few Copies of DNA with Carbon Nanotube Impedance Biosensors
Author(s) -
Kurkina Tetiana,
Vlandas Alexis,
Ahmad Ashraf,
Kern Klaus,
Balasubramanian Kannan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006806
Subject(s) - haystack , carbon nanotube , oligonucleotide , biosensor , nanotechnology , dna , electrical impedance , materials science , biology , computer science , genetics , physics , artificial intelligence , quantum mechanics
Finding that needle in the haystack : A label‐free on‐chip detection strategy based on carbon nanotubes (see picture) was used to detect an oligonucleotide target sequence of which less than 2000 copies were present in a 30 μL sample droplet, without the need for PCR. Instead, sensitive low‐noise impedance measurement coupled to field‐effect detection enabled attomolar DNA detection in a heterogeneous environment.