Premium
Synthesis of α‐Aryl Nitriles through Palladium‐Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates
Author(s) -
Shang Rui,
Ji DongSheng,
Chu Ling,
Fu Yao,
Liu Lei
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006763
Subject(s) - aryl , halide , salt (chemistry) , palladium , chemistry , catalysis , decarboxylation , combinatorial chemistry , phos , organic chemistry , medicinal chemistry , alkyl , biochemistry
Worth its salt : The palladium‐catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono‐ and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α‐aryl nitriles and has good functional group tolerance. S‐Phos=2‐(2,6‐dimethoxybiphenyl)dicyclohexylphosphine), Xant‐Phos=4,5‐bis(diphenylphosphino)‐9,9‐dimethylxanthene.