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Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging
Author(s) -
Lin Xin,
Xie Jin,
Zhu Lei,
Lee Seulki,
Niu Gang,
Ma Ying,
Kim Kwangmeyung,
Chen Xiaoyuan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006757
Subject(s) - ferritin , computer science , computational biology , protease , nanoparticle , matrix metalloproteinase , scaffold , chemistry , nanotechnology , cancer research , microbiology and biotechnology , biochemistry , materials science , biology , enzyme , database
Rattling the cage : Protein cages are used as a scaffold to build protease‐activatable probes. The self‐assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)‐specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor‐specific probe in a xenograft mouse model.