Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging | Zendy

Lin Xin | Zendy; Xie Jin | Zendy; Zhu Lei | Zendy; Lee Seulki | Zendy; Niu Gang | Zendy; Ma Ying | Zendy; Kim Kwangmeyung | Zendy; Chen Xiaoyuan | Zendy

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Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging

Author(s) -

Lin Xin,

Xie Jin,

Zhu Lei,

Lee Seulki,

Niu Gang,

Ma Ying,

Kim Kwangmeyung,

Chen Xiaoyuan

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201006757

Subject(s) - ferritin , computer science , computational biology , protease , nanoparticle , matrix metalloproteinase , scaffold , chemistry , nanotechnology , cancer research , microbiology and biotechnology , biochemistry , materials science , biology , enzyme , database

Rattling the cage : Protein cages are used as a scaffold to build protease‐activatable probes. The self‐assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)‐specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor‐specific probe in a xenograft mouse model.

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